The mechanism of itaconic acid formation by Aspergillus terreus. 2. The effect of substrates and inhibitors.
نویسندگان
چکیده
منابع مشابه
Biosynthesis of itaconic acid in Aspergillus terreus. II. Early stages in glucose dissimilation and the role of citrate.
We have shown that crude, cell-free extracts of Aspergillus terreus contain aconitase and cis-aconitic decarboxylase, and therefore quantitatively decarboxylate cis-aconitic, citric, and d-isocitric acids to itaconic acid and CO2 (1, 2). With use of labeled substrates, it has been shown that the isotope distributions in itaconic acid are consistent with the formation of cis-aconitic acid from c...
متن کاملExpression of the Aspergillus terreus itaconic acid biosynthesis cluster in Aspergillus niger
BACKGROUND Aspergillus terreus is a natural producer of itaconic acid and is currently used to produce itaconic acid on an industrial scale. The metabolic process for itaconic acid biosynthesis is very similar to the production of citric acid in Aspergillus niger. However, a key enzyme in A. niger, cis-aconitate decarboxylase, is missing. The introduction of the A. terreus cadA gene in A. niger...
متن کاملProduction of lovastatin and itaconic acid by Aspergillus terreus: a comparative perspective
Aspergillus terreus is a textbook example of an industrially relevant filamentous fungus. It is used for the biotechnological production of two valuable metabolites, namely itaconic acid and lovastatin. Itaconic acid serves as a precursor in polymer industry, whereas lovastatin found its place in the pharmaceutical market as a cholesterol-lowering statin drug and a precursor for semisynthetic s...
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Itaconic acid was best produced by fungal species than bacterial species. The A. niger and A. terreus were known to be the best species for itaconic acid production among the different fungal species studied. However, there was no comprehensive study on using latest technologies for increasing the productivity at industrial level and it was not properly established. By keeping this in view, the...
متن کاملUltraviolet-induced mutational changes in enzyme activity of Aspergillus terreus.
In previous publications Arpai (1957) and Arpai and Valentin (1957) described the production of ultraviolet-induced mutants of Aspergillus terreus, using nondifferentiated spore material and conidia differentiated by sedimentation rate. A limited number of the irradiated strains were morphologically altered and produced more itaconic acid than did the parent strain. The products of these strain...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 60 1 شماره
صفحات -
تاریخ انتشار 1955